标题：Regioselective Pyridine C-H-Functionalization and Skeletal Editing

报告时间：2025年9月23日(星期二) 15:00-15:55

报告地点：人民大街校区化学学院第三教室

主讲人：Armido Studer

主办单位：化学学院

报告内容简介：

Pyridines belong to the most abundant heteroarenes in medicinal chemistry and in agrochemical industry. In the lecture, highly regioselective pyridine C-H functionalization through a dearomatization/rearomatization sequence will be discussed. The dearomatized oxazino pyridines can be easily prepared on a large scale, and meta-functionalization becomes achievable through light-initiated radical alkylation and ionic transformations. As example, using such an approach meta-fluorinated pyridines are readily accessible. The same intermediates upon protonation to give the corresponding pyridinium salts also allow the highly regioselective radical Minisci para-alkylation. In addition, Cu-catalyzed meta-arylation and switchable radical para/meta-difluoromethylation through such intermediates will be presented. Radical meta-nitration and ionic meta-hydroxylation work equally well through such intermediates. Finally, it will be shown that this dearomatization concept is also applicable to pyridine skeletal editing. Further, it will be discussed that an alternative radical dearomatization process can be used for C to N mutation in indoles and benzofurans.

主讲人简介：

Armido Studer教授：现任德国明斯特大学有机化学正教授 (W3)，欧洲科学院院士、德国国家科学院院士和英国皇家化学会会士。以自由基化学为核心，系统开展自由基反应机理研究及相关应用开发，成果广泛应用于催化科学、有机合成方法学与先进材料化学等前沿领域。通过发展“持续自由基效应等理论，并提出“电子催化”新概念，课题组建立了自由基反应在选择性催化转化及功能分子精准合成中的新范式。在氮氧自由基化学方向取得多项突破，应用于表面功能化修饰、生物大分子精准偶联及复杂天然产物高效合成。Studer教授在Nature、Science、Nat. Synth. Nat. Chem.等国际顶级期刊发表研究论文400余篇，曾获阿道夫冯贝耶尔纪念奖章(2025)、Arthur C. Cope Late Carer Scholars Award (2022)和英国皇家化学会佩德勒奖 (2018)等荣誉称号。